The Patient-Centered Outcomes Research Institute (PCORI) has issued a request for applications for Improving Health Decision Making With Comparative Clinical Effectiveness Research: Retrospective Observational Studies Leveraging Existing Data Sources. This program will fund well-designed, retrospective observational studies that articulate a clear comparative effectiveness question by leveraging established data sources and infrastructure ready for patient-centered CER, including but not limited to PCORnet, the National Patient-Centered Clinical Research Network.
Given the retrospective observational nature of this PFA, applications are expected to compare existing interventions that represent a current decisional dilemma and have robust evidence of efficacy or are currently in widespread use. Clinical interventions (such as medications, diagnostic tests or procedures) and delivery system interventions (such as workforce, technologies and healthcare service delivery designs) are appropriate for these studies.
All proposed applications must respond to at least one of the following Topic Themes:
- Addressing Cancer
- Improving Outcomes for People with Intellectual and Developmental Disabilities
- Preventing Maternal Morbidity and Mortality
- Improving Mental and Behavioral Health
- Improving Metabolic and Endocrine Health
- Managing Pain
- Addressing Rare Diseases
- Addressing Sensory Health
- Addressing Substance Use
Up to $2,000,000 direct costs will be awarded, for a project period of 18 months.
To Apply:
- This is an open RFP (UCSF may submit an unlimited number of applications).
- Follow application instructions in RFP, conferring with your Grants Officer as needed. Please notify your Grants Officer as soon as possible of your intention to apply to ensure that they will have enough time to support your application.
- LOI deadline is January 6, 2026. If you are invited to submit a full application, the deadline will be May 5, 2026.
For more information and to review complete application instructions and eligibility requirements, please visit https://www.pcori.org/funding-opportunities/announcement/improving-health-decision-making-observational-comparative-clinical-effectiveness-research.