NIH Single IRB Mandate

Principal Investigator (PI) responsibilities in the identification and planning of NIH-supported multiple site studies, in which UCSF is the lead institution, that will require IRB review by one IRB per the NIH single IRB policy.

Determine if Single IRB is Required

If you answer YES to all three of the following questions, the proposal must follow NIH Policy on the Use of a Single Institutional Review Board for Multi-Site Research

  1. Does the proposal involve conducting non-exempt human subject research?
  2. Will there be multiple U.S. sites conducting the same protocol involving the non-exempt human subject research?
  3. Will the proposal be funded by NIH through a grant, cooperative agreement, or contract (excluding training awards)?

If you answered YES to all three questions (above), submit a sIRB consultation request to [email protected].

Start planning at least 90 days prior to the application submission due date